I am not convinced that the fresh new title faithfully shows the brand new contents of brand new papers

Authors’ effect

What is the method for determining fast-growing and slow-growing proteins-coding genes? In case the method is simply “Play with Ka”, I’d argue that individuals have complete that just before.

Authors’ response

I’ve altered the newest name to help you “Nonsynonymous replacing rate (Ka) are a comparatively uniform parameter having defining fast-growing and you can slow-developing necessary protein-programming genes”. I have looked the newest related literature carefully and now have maybe not discovered guides that have over such as for example comprehensive critiques on the strategies.


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Demuth JP, De Bie T, Stajich JE, Cristianini N, Hahn MW: Brand new progression away from mammalian gene group. PLoS You to definitely. 2006, 1: e85-/journal.pone.0000085.

Williamson SH, Hubisz MJ, Clark AG, Payseur BA, Bustamante Cd, Nielsen R: Localizing present adaptive progression throughout the peoples genome. PLoS Genet. 2007, 3: e90-/record.pgen.0030090.

Bustamante Computer game, Fledel-Alon A great, Williamson S, Nielsen Roentgen, Hubisz MT, Glanowski S, Tanenbaum DM, White TJ, Sninsky JJ, Hernandez RD, Civello D, Adams MD, Cargill M, Clark AG: Pure choice into necessary protein-programming genes from the person genome. Character. 2005, 437: 1153-1157. /nature04240.

Nielsen Roentgen, Bustamante C, Clark AG, Glanowski S, Sackton TB, Hubisz MJ, Fledel-Alon A, Tanenbaum DM, Civello D, Light TJ, J Sninsky J, Adams MD, Cargill Yards: A skim to own absolutely chosen family genes in the genomes of individuals and you may chimpanzees. PLoS Biol. 2005, 3: e170-/journal.pbio.0030170.

Kosiol C, Vinar T, weil Fonseca RR, Hubisz MJ, Bustamante Cd, Nielsen R, Siepel An effective: Activities out of positive possibilities in six Mammalian genomes. PLoS Genet. 2008, 4: e1000144-/journal.pgen.1000144.

Clark AG, Glanowski S, Nielsen Roentgen, Thomas PD, Kejariwal A, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang G, Zheng X, White TJ, Sninsky JJ, Adams MD, Cargill Meters: Inferring nonneutral progression out of peoples-chimp-mouse orthologous gene trios. Technology. 2003, 302: 1960-1963. /technology.1088821.

Locke DP, Hillier LW, Warren Bathroom, Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang Z, Chinwalla At, Minx P, ainsi que al: Comparative and you will demographic study of orang-utan genomes. Characteristics. 2011, 469: 529-533. /nature09687.

Gibbs RA, Rogers J, Katze Milligrams, Bumgarner Roentgen, Weinstock GM, Mardis Emergency room, Remington KA, Strausberg RL, Venter JC, Wilson RK, mais aussi al: Evolutionary and biomedical skills about rhesus macaque genome. Technology. 2007, 316: 222-234. /technology.1139247.

Wade CM, Giulotto Age, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey Age, Bellone RR, et al: Genome sequence, relative research, and you will inhabitants genetics of the home-based horse. Science. 2009, 326: 865-867. /research.1178158.

Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal Meters, Clamp M, Chang JL, Kulbokas EJ, Zody MC, mais aussi al: Genome series, comparative data and haplotype design of your own domestic puppy. Character. 2005, 438: 803-819. /nature04338.

Elsik CG, Tellam RL, Worley KC, Gibbs RA, Muzny DM, Weinstock GM, Adelson DL, Eichler EE, Elnitski L, Guigo R, mais aussi al: The newest genome series off taurine cattle: a windows to help you ruminant biology and you may evolution. Science. 2009, 324: 522-528. /science.1169588.

Waterston RH, Lindblad-Toh K, Birney Age, Rogers J, Abril JF, Agarwal P, Agarwala Roentgen, Ainscough R, Alexandersson Meters, A keen P, mais aussi al: First sequencing and comparative study of your own mouse genome. Characteristics. 2002, 420: 520-562. /nature01262.

Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott Grams, Steffen D, Worley KC, Burch PE, mais aussi al: Genome series of the Brown Norway rat returns facts to your mammalian evolution. Nature. 2004, 428: 493-521. /nature02426.

Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, http://www.datingranking.net/nl/jpeoplemeet-overzicht Chang JL, Duke S, Garber Meters, Gentles AJ, Goodstadt L, Heger A great, ainsi que al: Genome of the marsupial Monodelphis domestica reveals from inside the, 447: 167-177. /nature05805.


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